Much of our work involves evaluating critical care interventions as part of a long-term collaboration with the charity Intensive Care, National Audit and Research Centre (ICNARC).
CALORIES: a Phase III, open multicentre, randomised controlled trial comparing the clinical and cost-effectiveness of early nutritional support in critically ill patients via the parenteral versus the enteral route
E-MAIDEN: Epilepsy Management in Adults with Intellectual Disabilities by Epilepsy Nurses a multi-centre RCT of specially trained Epilepsy nurses for the support of adults with Epilepsy and Intellectual Disabilities (Collaborators: Cambridge University and MRC Biostatistics Research Unit)
LeoPARDS: Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis
PRoMISE: Protocolised Management in Sepsis a multicentre, randomised controlled trial of the clinical and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock
POPPI: Provision of Psychological support to people in intensive care
PERFORM: The management of febrile patients is one of the most common and important problems facing healthcare provider. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable and as a result innumerable patients worldwide undergo hospitalization invasive investigation and are treated with antibiotics for presumed bacterial infection when in fact they are suffering from self-resolving viral infection.
We aim to improve diagnosis and management of febrile patients by application of sophisticated phenotypic transcriptomic ©genomic proteomic® and bioinformatic approaches to well characterised large-scale multi≠national patient cohorts already recruited with EU funding. We will identify and validate promising new discriminators of bacterial and viral infection including transcriptomic and clinical phenotypic markers. The most accurate markers distinguishing bacterial and viral infection will be evaluated in prospective cohorts of patients reflecting the different health care settings across European countries. By linking sophisticated new genomic and proteomic approaches to careful clinical phenotyping and building on pilot data from our previous studies we will develop a comprehensive management plan for febrile patients which can be rolled out in healthcare systems across Europe.