Evidence synthesis and decision modelling
Decision analytic models provide estimates of resource use and outcomes associated with different policy, treatment and service provision choices. These models may be based on a single comparative study that represents a direct ‘experimental’ model of decision problem or may require synthesis of evidence from multiple studies. Decision models often entail extrapolation beyond the time horizon, comparators, endpoints and settings directly observed in comparative studies The synthesis and extrapolations require sophisticated statistical techniques including survival analysis and methods for causal inference.
Comprehensive Assessment of the HIV Prevention Role of Antiretroviral therapy (CAPRA)
Funder: NIHR programme grant
Economic evaluation of alternative strategies for maintaining the supply of blood to the NHS.
This project will include a Discrete Choice Experiment (DCE) to measure donor preferences for characteristics of the donor service and the donation experience, and a Discrete Event Simulation (DES) to model the impact of any changes on donations made by the UK’s blood donors.
Mark Pennington, Richard Grieve, John Cairns, Neil Hawkins
Collaborators: NHS Blood and Transplant
Bernadette Li; John Cairns
Funder: NIHR Programme grant
Learning Together: Initiating change locally in bullying and aggression through the school environment
Funder: NIHR Health Technology Assessment Programme
NIHR Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections
The aim of this policy unit is to conduct state-of-the-art research to improve the health of the population, and to help develop practical policy guidelines for those working in health.
Funding: NIHR and Public Health England
Outcomes in Ankle Replacement Study (OARS), in which he is undertaking a cost-effectiveness analysis of ankle replacement compared to fusion
Collaborators: UEA and UCL
Funder: Arthritis Research UK
Prevention ANd Testing for HIV: Economics and Outcomes of Novel Approaches (PANTHEON) to assess the cost-effectiveness of HIV prevention and testing strategies, including HIV self-testing, among men who have sex with men in the UK
Funder: NIHR Programme grant
PROMPTS – An RCT to evaluate the cost-effectiveness of a MRI to prevent the onset of spinal cord compression in people with metastatic prostate cancer
Alec Miners, Sarah Willis
Collaborator: Institute for Cancer Research
Funder: Cancer Research UK
SANTE – Sexual risk reduction interventions for patients attending sexual health clinics; feasibility to conduct and effectiveness trial.
This study aims to design and pilot an intervention for reducing future high risk behaviour in people attending sexual health clinics for a STI test in the UK; it includes a discrete choice experiment
Funder: NIHR HTA grant
SmartTarget: An early economic evaluation of a novel device which aims to put information on the location of cancer from medical imaging is at the centre of the diagnosis and treatment of prostate cancer
Jan van der Meulen; Alec Miners; Sarah Willis
Collaborators: UCL Division of Surgery and Interventional Science, UCLH NHS Foundation Trust, UCL Centre for Medical Image Computing
Funder: Health Innovation Challenge Fund (jointly funded by the Wellcome Trust and UK Department of Health)
STOP-HCV. A MRC funded stratified medicines work programme/consortia to optimise the treatment of people with HCV
Collaborators: Oxford University
SUPREMO: a phase III randomised trial to assess the Selective Use of Postoperative Radiotherapy AftEr MastectOmy
John Cairns; Sarah Willis
Collaborators: University of Edinburgh
The lifetime effects, costs and cost-effectiveness of endometrial cancer screening
Funder: Cancer Research UK Population Research Committee Project Grant