Evidence synthesis and decision modelling

Decision analytic models provide estimates of resource use and outcomes associated with different policy, treatment and service provision choices. These models may be based on a single comparative study that represents a direct ‘experimental’ model of decision problem or may require synthesis of evidence from multiple studies. Decision models often entail extrapolation beyond the time horizon, comparators, endpoints and settings directly observed in comparative studies The synthesis and extrapolations require sophisticated statistical techniques including survival analysis and methods for causal inference.

Key people: Neil Hawkins, Alec Miners, Rosa LegoodJohn CairnsSarah Willis

 


KEY PROJECTS

Comprehensive Assessment of the HIV Prevention Role of Antiretroviral therapy (CAPRA)

Alec Miners

Collaborators: UCL

Funder: NIHR programme grant


Economic evaluation of alternative strategies for maintaining the supply of blood to the NHS.

This project will include a Discrete Choice Experiment (DCE) to measure donor preferences for characteristics of the donor service and the donation experience, and a Discrete Event Simulation (DES) to model the impact of any changes on donations made by the UK’s blood donors.

Mark Pennington, Richard Grieve, John Cairns, Neil Hawkins

Collaborators: NHS Blood and Transplant

Funder: NIHR


Economic evaluation of alternative kidney allocation schemes for the Access to Transplantation and Transplant Outcome Measures (ATTOM) study

Bernadette Li; John Cairns

Funder: NIHR Programme grant


Learning Together: Initiating change locally in bullying and aggression through the school environment

Rosa Legood

Funder: NIHR Health Technology Assessment Programme


NIHR Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections

The aim of this policy unit is to conduct state-of-the-art research to improve the health of the population, and to help develop practical policy guidelines for those working in health.

Alec Miners

Collaborators: UCL

Funding: NIHR and Public Health England


Outcomes in Ankle Replacement Study (OARS), in which he is undertaking a cost-effectiveness analysis of ankle replacement compared to fusion

Mark Pennington

Collaborators: UEA and UCL

Funder: Arthritis Research UK


Prevention ANd Testing for HIV: Economics and Outcomes of Novel Approaches (PANTHEON) to assess the cost-effectiveness of HIV prevention and testing strategies, including HIV self-testing, among men who have sex with men in the UK

Alec Miners

Collaborators: UCL

Funder: NIHR Programme grant


PROMPTS – An RCT to evaluate the cost-effectiveness of a MRI to prevent the onset of spinal cord compression in people with metastatic prostate cancer

Alec Miners, Sarah Willis

Collaborator: Institute for Cancer Research

Funder: Cancer Research UK


SANTE – Sexual risk reduction interventions for patients attending sexual health clinics; feasibility to conduct and effectiveness trial.

This study aims to design and pilot an intervention for reducing future high risk behaviour in people attending sexual health clinics for a STI test in the UK; it includes a discrete choice experiment

Alec Miners

Collaborators: UCL

Funder: NIHR HTA grant


SmartTarget: An early economic evaluation of a novel device which aims to put information on the location of cancer from medical imaging is at the centre of the diagnosis and treatment of prostate cancer

Jan van der Meulen; Alec Miners; Sarah Willis

Collaborators: UCL Division of Surgery and Interventional Science, UCLH NHS Foundation Trust, UCL Centre for Medical Image Computing

Funder: Health Innovation Challenge Fund (jointly funded by the Wellcome Trust and UK Department of Health)


STOP-HCV. A MRC funded stratified medicines work programme/consortia to optimise the treatment of people with HCV

Alec Miners

Collaborators: Oxford University

Funder: MRC


SUPREMO: a phase III randomised trial to assess the Selective Use of Postoperative Radiotherapy AftEr MastectOmy

John Cairns; Sarah Willis

Collaborators: University of Edinburgh

Funder: MRC


The lifetime effects, costs and cost-effectiveness of endometrial cancer screening

Rosa Legood

Funder: Cancer Research UK Population Research Committee Project Grant

 

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